Nattokinase: Prevention and Treatment of Heart Conditions
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چکیده
E nzyme therapies are becoming more prevalent in medicine today, with many manufacturers targeting their advantages in disease treatment. In the last 100 years, enzymes have been increasingly used to treat various diseases. Early observations of Bacillus pyocyaneus revealed that its secretions could destroy anthrax bacilli and protect mice from inoculation with this deadly bacterium. Scientists deduced that the secretions were able to destroy anthrax by chewing apart its nucleic acids, via enzymatic degradation. This early observation paved the way for the use of enzymes in medicine. Today, enzymes are used as oncolytics, anticoagulants, thrombolytics, anti-inflammatories, fibrinolytics, mucolytics, antimicrobials, and digestive aids. Enzymes are found throughout the natural world; the number of uses for them in various fields of industry in addition to medicine is staggering. Enzymes are found in animal and plant sources. Enzymes can be thought of as protein molecules with a specific mission—to initiate and regulate countless biologic reactions in living organisms. Enzymes are used for metabolic and digestive processes. Metabolic enzymes greatly increase the speed at which chemical processes take place within the body; without enzymes, cells could not perform their multiple functions. Every aspect of life depends on the energetic stimulus that enzymes provide. Perhaps therapeutic enzymes are used most often for enhancing digestive function. Enzymes help food break down into its smallest components. Enzymes secreted by humans include pepsin and protease for breakdown of proteins, lipase for fats, and amylase for carbohydrates. Cellulase, which helps with digest ion of plant cel ls , is not produced by humans but is extracted from plant t issues as they are mechanically broken down. Plant-based foods are often cooked but heat destroys enzymes; a plant food in its raw, fresh state produces considerably more enzyme activity than one that has been cooked. Mechanisms of Action
منابع مشابه
Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase.
The existence of a potent fibrinolytic enzyme (nattokinase, NK) in the traditional fermented food called 'natto', was reported by us previously. It was confirmed that oral administration of NK (or natto) produced a mild and frequent enhancement of the fibrinolytic activity in the plasma, as indicated by the fibrinolytic parameters, and the production of tissue plasminogen activator. NK capsules...
متن کاملNattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease
Natto, a fermented soybean product, has been consumed as a traditional food in Japan for thousands of years. Nattokinase (NK), a potent blood-clot dissolving protein used for the treatment of cardiovascular diseases, is produced by the bacterium Bacillus subtilis during the fermentation of soybeans to produce Natto. NK has been extensively studied in Japan, Korea, and China. Recently, the fibri...
متن کاملLipid-Lowering Effect of Nattokinase in Patients with Primary Hypercholesterolemia
Background: Nattokinase is a fibrinolytic enzyme isolated from the vegetable cheese natto. Although research suggests that nattokinase has beneficial effects on lipid metabolism, there is no clinical data on its effects in human patients with hypercholesterolemia. Methods: Thirty patients with primary hypercholesterolemia given instruction on a low cholesterol diet and treated with 400 mg (4000...
متن کاملExperimental Evaluation of the Effect of Endothelin Receptor Antagonist on Nattokinase Induced Change in Heart Rate and Biochemical Parameters in the Rat
Nattokinase is a potent fibrinolytic enzyme, obtained from ‘natto’ a traditional food in Japan. It breaks fibrin strands both by hydrolyzing fibrin in blood clots directly and hastens the production of tissue plasminogen Activator. It was also found to be lower the blood pressure and has been used in the management of atherosclerosis, coronary artery disease, and stroke. Endothelin-1 (ET-1) is ...
متن کاملConsumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial
OBJECTIVE The objective of this study is to evaluate the effects of consumption of nattokinase on hypertension in a North American hypertensive population with associated genetic, dietary, and lifestyle factors. This is in extension of, and contrast to, previous studies on Asian populations. MATERIALS AND METHODS A randomized, double-blind, placebo-controlled, parallel-arm clinical study was ...
متن کاملDevelopment of surface-engineered PLGA nanoparticulate-delivery system of Tet1-conjugated nattokinase enzyme for inhibition of Aβ40 plaques in Alzheimer’s disease
According to the World Health Organization, globally there are around 18 million patients suffering from Alzheimer's disease (AD), and this number is expected to double by 2025. The pathophysiology of AD includes selective deposition of Aβ peptide in the mitochondria of cells, which inhibits uptake of glucose by neurons and key enzyme functions. Current drug treatments for AD are unable to rect...
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تاریخ انتشار 2005